![]() ![]() ![]() An ideal radiotracer for myocardial perfusion imaging should have a high myocardial uptake a high and stable target-to-background ratio with low uptake in the lungs, liver, stomach during the image acquisition period a high first-pass myocardial extraction fraction and very rapid blood clearance and a linear relationship between radiotracer myocardial uptake and coronary blood flow. ![]() Despite their widespread clinical applications, both Tc-Sestamibi and Tc-Tetrofosmin do not meet the requirements of an ideal perfusion imaging agent due to their relatively low first-pass extraction fraction and high liver absorption. Despite its peculiar properties, the clinical use of Tc-Teboroxime was quickly abandoned due to its rapid myocardial washout. In the early 1980s, Tc-Sestamibi, Tc-Tetrofosmin, and Tc-Teboroxime were approved as commercial radiopharmaceuticals for myocardial perfusion imaging in nuclear cardiology. The favorable nuclear properties in combination with the rich coordination chemistry make technetium-99m the radioisotope of choice for the development of myocardial perfusion tracers. ![]()
0 Comments
Leave a Reply. |